diff --git a/src/amd/llvm/ac_llvm_build.c b/src/amd/llvm/ac_llvm_build.c
index c1aebfe3ed3..869530c5050 100644
--- a/src/amd/llvm/ac_llvm_build.c
+++ b/src/amd/llvm/ac_llvm_build.c
@@ -1060,6 +1060,7 @@ static LLVMValueRef ac_build_load_custom(struct ac_llvm_context *ctx, LLVMValueR
    result = LLVMBuildLoad(ctx->builder, pointer, "");
    if (invariant)
       LLVMSetMetadata(result, ctx->invariant_load_md_kind, ctx->empty_md);
+   LLVMSetAlignment(result, 4);
    return result;
 }
 
@@ -4692,7 +4693,7 @@ LLVMValueRef ac_build_main(const struct ac_shader_args *args, struct ac_llvm_con
       if (LLVMGetTypeKind(LLVMTypeOf(P)) == LLVMPointerTypeKind) {
          ac_add_function_attr(ctx->context, main_function, i + 1, AC_FUNC_ATTR_NOALIAS);
          ac_add_attr_dereferenceable(P, UINT64_MAX);
-         ac_add_attr_alignment(P, 32);
+         ac_add_attr_alignment(P, 4);
       }
    }
 
diff --git a/src/amd/vulkan/radv_nir_to_llvm.c b/src/amd/vulkan/radv_nir_to_llvm.c
index e72e091f909..3be4e195b7b 100644
--- a/src/amd/vulkan/radv_nir_to_llvm.c
+++ b/src/amd/vulkan/radv_nir_to_llvm.c
@@ -122,6 +122,7 @@ load_descriptor_sets(struct radv_shader_context *ctx)
 
          ctx->descriptor_sets[i] =
             ac_build_load_to_sgpr(&ctx->ac, desc_sets, LLVMConstInt(ctx->ac.i32, i, false));
+         LLVMSetAlignment(ctx->descriptor_sets[i], 4);
       }
    } else {
       while (mask) {
@@ -445,6 +446,7 @@ radv_load_ssbo(struct ac_shader_abi *abi, LLVMValueRef buffer_ptr, bool write, b
 
    result = LLVMBuildLoad(ctx->ac.builder, buffer_ptr, "");
    LLVMSetMetadata(result, ctx->ac.invariant_load_md_kind, ctx->ac.empty_md);
+   LLVMSetAlignment(result, 4);
 
    return result;
 }
@@ -494,6 +496,7 @@ radv_load_ubo(struct ac_shader_abi *abi, unsigned desc_set, unsigned binding, bo
 
    result = LLVMBuildLoad(ctx->ac.builder, buffer_ptr, "");
    LLVMSetMetadata(result, ctx->ac.invariant_load_md_kind, ctx->ac.empty_md);
+   LLVMSetAlignment(result, 4);
 
    return result;
 }